Sepsis is a life-threatening organ dysfunction caused by the host's imbalance in response to infection.Septic cardiomyopathy is a complication of severe sepsis and septic shock,with high mortality and poor prognosis.However,the pathophysiological mechanism of septic cardiomyopathy is currently unclear,and there is no targeted treatment measure.The purpose of this review is to summarize the current research on the mechanism of myocardial dysfunction caused by sepsis,and provide new ideas for future research and intervention direction.