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脓毒症心肌病的发病机制研究进展

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脓毒症是宿主对感染的反应失调而导致威胁生命的器官功能障碍,脓毒症心肌病是严重脓毒症和脓毒性休克的并发症,死亡率高,预后不良,但目前脓毒症心肌病的病理生理机制暂不明确,尚无针对性的治疗措施。现总结目前关于脓毒症引起心肌功能障碍相关机制的研究现状,为未来的研究和干预方向提供新思路。
Pathogenesis of Septic Cardiomyopathy
Sepsis is a life-threatening organ dysfunction caused by the host's imbalance in response to infection.Septic cardiomyopathy is a complication of severe sepsis and septic shock,with high mortality and poor prognosis.However,the pathophysiological mechanism of septic cardiomyopathy is currently unclear,and there is no targeted treatment measure.The purpose of this review is to summarize the current research on the mechanism of myocardial dysfunction caused by sepsis,and provide new ideas for future research and intervention direction.

J Septic cardiomyopathyDamage-associated molecular patternPathogen-associated molecular patternMitochondrial dysfunctionFerroptosisPyroptosis

李心瑶、陈俊、李灼

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南京医科大学附属儿童医院急诊/重症医学科,江苏南京 210008

脓毒症心肌病 损伤相关分子模式 病原体相关分子模式 线粒体功能障碍 铁死亡 细胞焦亡

南京市医学科技发展基金资助项目

YKK20130

2024

心血管病学进展
成都市心血管病研究所,成都市第三人民医院

心血管病学进展

CSTPCD
影响因子:0.932
ISSN:1004-3934
年,卷(期):2024.45(1)
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