Mitochondrial dynamics refers to mitochondrial fission and fusion in order to maintain the dynamic balance of the mitochondrial network and provide energy to the cell.The advancement of atherosclerosis(AS)is directly linked to an imbalance in mitochondrial dynamics caused by a variety of causes,particularly abnormal mitochondrial fission.Dynamic related protein 1(Drp1)is the most critical protein that mediates mitochondrial division.The increased expression of Drp1 in AS interacts with pathological factors related to AS,such as endothelial cell senescence,proliferation and migration of vascular smooth muscle cells,and transformation to osteoblast-like cells,macrophage-involved cholesterol efflux and inflammation,thereby accelerating the disease progression.In addition,inhibitors of Drp1 and some herbal extracts have been shown to be dependent on the Drp1 pathway to decelerate AS progression.This article elaborates on the structure and activity regulation of Drp1,its key role in the progression of AS,and the current research status of targeted Drp1 therapy for AS.
AtherosclerosisMitochondrionDynamin-related protein 1
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