Clinical Application Progress of 18F-NaF Positron Emission Tomography in Arterial Plaque Imaging
Atherosclerotic plaque rupture is the main cause of sudden cardiac death,and the progress of calcification is also an important predictor of cardiovascular risk,but it is difficult to predict the occurrence of plaque rupture and evaluate the progress of calcification.In recent years,the rapid development of molecular imaging technology makes it possible to identify high-risk plaques non-invasively.18F-sodium fluoride positron emission tomography(18F-NaF PET)is a noninvasive imaging method that can be used for detection of arterial high-risk plaques,which can not only identify plaques with active calcification,stratify patients at risk,but also monitor the progression of vascular calcification,guide treatment intervention,and evaluate the efficacy of anti-atherosclerosis drugs to promote the improvement of treatment.In this paper,the mechanism of 18F-NaF PET imaging,the ability to identify vulnerable plaques,risk stratification and prognosis judgment are reviewed.
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