Role of NLRP3 Inflammasome in Heart Failure and Related Therapy
Heart failure is the end stage of many cardiovascular diseases and its prevalence is increasing due to the aging population and the increased burden of heart failure comorbidities and risk factors.Despite tremendous advances in its diagnosis and treatment over the decades,specific and effective therapeutic options are still lacking.NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome is a protein complex that can participate in the pathophysiological process of ventricular remodeling,which in turn affects the onset and progression of heart failure.Inhibition of NLRP3 inflammasome activation is a feasible strategy to reduce adverse ventricular remodeling and improve left ventricular function in heart failure.The structural functions,activation pathways,roles in heart failure,and related therapies of NLRP3 inflammasome are reviewed.
Heart failureVentricular remodelingNOD-like receptor thermal protein domain associated protein 3 inflamm-asomeInflammation
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