The damage of cardiovascular structure and function is an important pathological basis of many cardiovascular diseases.Many studies have shown that oxidative stress plays an important role in many pathological cardiovascular injuries,such as ischemic heart disease,atherosclerosis,hypertension,etc.Reduced nicotinamide adenine dinucleotide phosphate oxidase(Nox)is a key enzyme in the regulation of redox signaling,and intravascular reactive oxygen species are mainly originated from Nox4.With the deepening of the research,it has been found that Nox4 plays different or even opposite roles at different stages or under different stimuli,such as bidirectional regulation of atherosclerosis progression,bidirectional effects affecting blood pressure,etc.This article summarizes the different roles and mechanisms of Nox4 in different cardiovascular injuries,providing a theoretical basis for subsequent research.
维普
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