首页|免疫检查点抑制剂相关动脉粥样硬化性心血管疾病研究进展

免疫检查点抑制剂相关动脉粥样硬化性心血管疾病研究进展

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近年来,免疫检查点抑制剂的出现改变了多种恶性肿瘤的治疗方式,但其常造成包括心血管系统在内的免疫相关不良事件。诸多对免疫检查点抑制剂治疗相关心血管不良事件的研究主要局限在心肌炎,而最近一些临床研究表明,免疫检查点抑制剂与动脉粥样硬化的发展和恶化可能相关。现就免疫检查点抑制剂相关动脉粥样硬化性心血管疾病可能的病理机制及临床意义进行综述,以期提高临床医生对动脉粥样硬化性心血管疾病的意识并警惕其发生。
Immune Checkpoint Inhibitor Related Atherosclerotic Cardiovascular Disease
While immune checkpoint inhibitors have transformed how some malignant tumors are treated in recent years,it has also resulted in the occurrence of unique immune-related adverse events,including the cardiovascular system.Some recent clinical research suggests that immune checkpoint inhibitors may be connected to the onset and progression of atherosclerosis,however many investigations on cardiovascular adverse events due to treatment with immune checkpoint inhibitors are primarily limited to myocarditis.This article reviews the possible pathological mechanism and clinical significance of immune checkpoint inhibitors related atherosclerotic cardiovascular disease,in order to improve clinicians'awareness of atherosclerosis cardiovascular disease and guard against its occurrence.

Immune checkpoint inhibitorAtherosclerotic cardiovascular diseaseImmune-related adverse eventMechanism

陆睿、廖祎、王敏、林心情、鲁明军

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广州医科大学附属第一医院心血管内科,广东广州 510120

广州医科大学附属第一医院呼吸内科,广东广州 510120

免疫检查点抑制剂 动脉粥样硬化性心血管疾病 免疫相关不良事件 机制

广州市科技计划广东省援疆科技项目

2021020101802017B0202470

2024

心血管病学进展
成都市心血管病研究所,成都市第三人民医院

心血管病学进展

CSTPCD
影响因子:0.932
ISSN:1004-3934
年,卷(期):2024.45(2)
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