摘要
血管内皮功能对维持心血管系统稳态至关重要,其功能障碍是心血管疾病的重要原因.近年来,许多研究表明肠道菌群参与了血管内皮功能的改变,可能通过直接影响肠道菌群或间接影响肠道菌群代谢产物,如短链脂肪酸、次级胆汁酸、吲哚-3-甲醛、三甲胺-N-氧化物、苯乙酰谷氨酰胺、脂多糖、尿毒症毒素等对血管内皮功能产生影响.现综述近年来发现的肠道菌群代谢产物,为探索肠道菌群对血管内皮功能的影响提供理论基础和新思路.
Abstract
Vascular endothelial function is critical for maintaining homeostasis of the cardiovascular system,and its dysfunction is an important cause of cardiovascular disease.In recent years,many studies have shown that intestinal flora are involved in the alteration of vascular endothelial function,which may affect vascular endothelial function by directly influencing intestinal flora or indirectly influencing intestinal flora metabolites,such as short-chain fatty acids,secondary bile acids,indole-3-carboxaldehyde,trimethylamine-N-oxides,phenylacetylglutamine,lipopolysaccharides,and uremic toxins.The metabolites of intestinal flora discovered in recent years are reviewed to provide a theoretical basis and new ideas for exploring the effects of intestinal flora on vascular endothelial function.
基金项目
陕西省重点研发计划(2021ZDLSF02-03)
维普
万方数据