Ischemic heart disease seriously endangers human health.Myocardial ischemia-reperfusion injury(MIRI)is the most common pathophysiological damage.How to prevent or reduce its damage has become a key issue.Previous research results have shown that cellular oxidative induction,inflammation,apoptosis and autophagy have an important impact on the pathogenesis and pathophysiological process of MIRI.Autophagy plays a key role,and moderate autophagy helps maintain the normal function of the heart.Long noncoding RNA can participate in the MIRI by regulating autophagy,and its abnormal expression and function have attracted more attention.However,the specific mechanism of action is still unclear and its clinical application is limited.Therefore,by reviewing the research progress of long non-coding RNA regulating autophagy in MIRI,it provides a certain theoretical basis for improving MIRI treatment strategies and discovering new therapeutic targets to protect myocardium.
Long non-coding RNAAutophagyMyocardial ischemia-reperfusion injuryMyocardial injury
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