Late stent thrombosis is a major complication of percutaneous coronary intervention(PCI)therapy,which seriously affects the prognosis of patients with atherosclerotic cardiovascular disease and causes irreversible harm.Reendothelialization of damaged vessels after PCI therapy is available to reduce late stent thrombosis.The mechanisms of reendothelialization mainly include the adhesion and proliferation of endothelial cell,the adhesion and proliferation of smooth muscle cell,the adhesive aggregation and activation of platelet,and the absorption of fibrinogen.The study on the mechanism of reendothelialization of vascular injury in patients with atherosclerotic cardiovascular disease provides new views and therapeutic targets for vascular remodeling after injury,which is conducive to improving the prognosis of patients undergoing PCI.This article reviews the relevant mechanism and therapy of reendothelialization of injured vessels after PCI.
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