Mitochondrial Dysfunction and the Development of Vascular Calcification
Vascular calcification is a prevalent pathological phenomenon in senescence,atherosclerosis,chronic kidney disease and diabetes mellitus.Mitochondrial DNA damage,alterations in the mitochondrial microenvironment and abnormal mitochondrial autophagy can affect the occurrence and development of vascular calcification by altering mitochondrial function.The role of mitochondrial dysfunction in the process of vascular calcification has not been fully elucidated yet.In this paper,we will explore the role of mitochondrial dysfunction and related mechanism in regulating vascular calcification,and provide therapeutic ideas for clinical treatment of vascular calcification.
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