The Mechanisms of SIRT1-Mediated Signal Pathway in Doxorubicin-Induced Cardiotoxicity
Silence information regulator 1(SIRT1)plays a protective role in doxorubicin-induced cardiotoxicity by mediating a variety of signaling pathways to participate in the regulation of oxidative stress,mitochondrial function,apoptosis,inflammatory response,endoplasmic reticulum stress,fibrosis and other pathological and physiological processes.This review summarizes the mechanisms of SIRT1-mediated signaling pathways in doxorubicin-induced cardiotoxicity.
Silence information regulator 1Signal pathwayDoxorubicinCardiotoxicity
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