Regulatory Mechanism of Ferroptosis and Its Progress in Anthracycline-Induced Cardiotoxicity
Ferroptosis is a new mode of cell death caused by iron-mediated accumulation of lipid peroxidation,which plays an important role in cardiovascular diseases.Anthracyclines are one of the most commonly used chemotherapeutic agents for the treatment of cancers.Although the drugs are effective,their benefits are sometimes compromised by acute and/or delayed cardiotoxic side effects,especially heart failure.Evidence suggests that anthracycline-induced cardiotoxicity is closely related to cardiomyocyte ferroptosis,and the mechanisms of ferroptosis in the development of anthracycline-induced cardiotoxicity and potential therapeutic targets are reviewed.We hope to provide new therapeutic target and research direction for attenuating the myocardial damage caused by anthracyclines.
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