铁死亡的调控机制及其在蒽环类药物心脏毒性中的研究进展
Regulatory Mechanism of Ferroptosis and Its Progress in Anthracycline-Induced Cardiotoxicity
赵珂 1陈晓姝 2魏希进 3张娟 3刘杨 3卞雨敬 1袁杰3
作者信息
- 1. 山东中医药大学第一临床医学院,山东 济南 250000
- 2. 东明县卫生健康局,山东 菏泽 274000
- 3. 山东中医药大学附属医院,山东济南 250000
- 折叠
摘要
铁死亡是由铁介导的脂质过氧化累积引起的一种新的细胞死亡模式,在心血管疾病中发挥重要作用.蒽环类药物是最常用的化疗药物之一,用于治疗多种癌症.虽然药物有效,但其益处有时会受到急性和/或迟发性心脏毒性副作用(尤其是心力衰竭)的影响.证据表明蒽环类药物心脏毒性与心肌细胞铁死亡密切相关,现就铁死亡在蒽环类药物心脏毒性发生过程中的机制及潜在的治疗靶点进行综述,以期为减弱蒽环类化疗药物所致心肌损伤提供新的治疗靶点与研究方向.
Abstract
Ferroptosis is a new mode of cell death caused by iron-mediated accumulation of lipid peroxidation,which plays an important role in cardiovascular diseases.Anthracyclines are one of the most commonly used chemotherapeutic agents for the treatment of cancers.Although the drugs are effective,their benefits are sometimes compromised by acute and/or delayed cardiotoxic side effects,especially heart failure.Evidence suggests that anthracycline-induced cardiotoxicity is closely related to cardiomyocyte ferroptosis,and the mechanisms of ferroptosis in the development of anthracycline-induced cardiotoxicity and potential therapeutic targets are reviewed.We hope to provide new therapeutic target and research direction for attenuating the myocardial damage caused by anthracyclines.
关键词
铁死亡/蒽环类药物/心脏毒性/脂质过氧化/铁积累Key words
Ferroptosis/Anthracycline/Cardiotoxicity/Lipid peroxidation/Iron accumulation引用本文复制引用
基金项目
山东省自然科学基金联合基金重点支持项目(ZR2021LZY038)
齐鲁医派中医药特色技术整理推广项目(鲁卫函[2022]93号)
山东省老年医学学会2021年科技攻关项目(LKJGG2021W106)
出版年
2024
NETL
NSTL
万方数据