Research Progress of Autophagy in Coronary Atherosclerotic Heart Disease
Coronary atherosclerotic heart disease(CHD)is the most common cause of death worldwide.Autophagy,or macroautophagy,is a survival mechanism that refers to the process of phagocytosis of cytoplasmic components into the double-membrane autophagosome,which is subsequently passed on to lysosome for degradation,thereby keeping cells alive by recycling the digested cellular components.Autophagy is an adaptive response that is essential for cell growth,survival and homeostasis.Recently,autophagy has been found to be closely related to the occurrence and development of CHD.Normal autophagy has a protective effect on cardiomyocytes,and insufficient or excessive autophagy can aggravate the progression of CHD.The article reviews the research progress of autophagy in CHD.
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