Ischemic heart disease is a prominent global cause of mortality.The mammalian target of rapamycin(mTOR)is a serine/threonine protein kinase that regulates protein synthesis,cell growth,proliferation,and autophagy.Recent research has substantiated the significant role played by mTOR in the pathogenesis and progression of ischemic heart disease.This article provides an overview of the advancements made in understanding mTOR and its associated signaling pathways in relation to ischemic heart disease,aiming to offer novel insights for clinical treatment strategies and drug development.
关键词
哺乳动物雷帕霉素靶蛋白/缺血性心脏病/缺血再灌注/缺血性心力衰竭/心脏重构
Key words
Mammalian target of rapamycin/Ischemic heart disease/Ischemia reperfusion/Ischemic heart failure/Cardiac remodeling
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