Kounis syndrome is a type of hypersensitivity reaction disease that occurs due to allergic reactions to diseases,foods,drugs,or environmental factors.It is characterized by symptoms such as rash,urticaria,itching,nausea,vomiting,wheezing,and angioedema.This condition affects the coronary artery system,leading to the occurrence of acute coronary syndrome,which is commonly manifested as chest pain,chest discomfort,shortness of breath,and palpitations.The treatment of this disease faces certain challenges because there is very limited available data on treatment strategies for Kounis syndrome.Many doctors have little knowledge of Kounis syndrome,which also contributes to the lack of understanding and reporting of this disease.Therefore,it is important for clinical physicians to have an understanding of Kounis syndrome in order to promptly diagnose and manage patients with Kounis syndrome encountered in clinical practice.This article provides a comprehensive summary of Kounis syndrome,aiming to offer guidance for further clinical understanding of this condition.