Atrial fibrillation is a kind of arrhythmia with complex pathophysiological mechanism.A large number of clinical trials and animal experiments have shown that atrial structural remodeling and electrical remodeling mediated by inflammatory factors are important pathophysiological basis for inducing atrial fibrillation,and the interleukin(IL)family is most closely related to atrial fibrillation.This article briefly reviews the relationship between IL-1(3,IL-6,IL-10,IL-17,and IL-22 and atrial fibrillation,and the application of IL-receptor antagonists in cardiovascular disease.