摘要
白细胞介素(IL)-13属于Th2细胞因子家族中的一员,具有重要的免疫调节活性,与多种免疫细胞相互作用产生影响,而近年来IL-13与心肌损伤的关系受到关注.心肌损伤表现为心肌细胞的缺血、缺氧、损伤及坏死,最终导致心肌功能失常,可由多种疾病引起,如冠心病、心力衰竭、心肌炎等.现对IL-13与免疫细胞如单核巨噬细胞、T细胞、嗜酸性粒细胞在心肌损伤机制中的相互作用做一综述.
Abstract
Interleukin(IL)-13 is a member of Th2 cytokine family,which has important immunomodulatory activities and interacts with a variety of immunocytes.In recent years,the relationship between IL-13 and myocardial injury has attracted attention.Myocardial injury is manifested as ischemia,hypoxia,injury and necrosis of myocardial cells,and eventually lead to myocardial dysfunction,which can be caused by a variety of diseases,such as coronary heart disease,heart failure,myocarditis and so on.This article reviews the interaction between IL-13 and immunocyte such as monocyte-macrophages,T lymphocytes,and eosinophils in the mechanism of myocardial injury.
基金项目
内蒙古自治区高等学校科研项目(NJZY23143)
内蒙古医科大学"三位一体"大学生创新创业训练计划培育项目(SWYT2022022)
维普
万方数据