Non-malignant clonal amplification of somatic cell mutation in hematopoietic system is called clonal hematopoiesis,which is a process of increasing the proportion of mutant white blood cells after driving gene mutation.The genetic patterns of clonal hematopoiesis include leukemia driver gene mutation,autosomal mosaic chromosome alternation and sex chromosome deletion.Recent studies have pointed out that clonal hematopoiesis caused by leukemia driver gene mutation or white blood cell Y chromosome mosaic deletion will affect the occurrence and development of various cardiovascular disease(including atherosclerosis,heart failure and cardiac fibrosis).More and more evidence shows that clonal hematopoiesis is a new mechanism of cardiovascular disease and a new kind of risk factor,which is as important as traditional risk factors.Therefore,this paper analyzes the genetic model of clonal hematopoiesis and summarizes the correlation between clonal hematopoiesis and cardiovascular disease.
关键词
克隆性造血/心血管疾病/体细胞突变/Y染色体缺失/炎症反应
Key words
Clonal hematopoiesis/Cardiovascular disease/Somatic mutation/Loss of Y chromosome/Inflammatory reaction
维普
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