Cardiovascular disease has received extensive attention due to its prevalence and high mortality.The severity of atherosclerosis has an important impact on the development of cardiovascular disease.Lipoprotein-associated phospholipase A2(Lp-PLA2)has attracted much attention as a biomarker of vascular inflammation and vulnerability to atherosclerotic plaque.In the past 20 years,people have conducted a large number of studies on Lp-PLA2 at the gene level,and found that 62％of the genetic factors may affect the variation of Lp-PLA2 activity,and the gene polymorphism may affect the function of Lp-PLA2,thus further affecting the progress of related diseases.This article is to explore the association between Lp-PLA2 gene V279F,A379V,1198T,R92H polymorphism and cardiovascular disease,so as to further understand the effect of gene polymorphism on Lp-PLA2 function.
维普
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