Functional Analysis of Lp-PLA2 Gene Polymorphisms in Cardiovascular Disease
Cardiovascular disease has received extensive attention due to its prevalence and high mortality.The severity of atherosclerosis has an important impact on the development of cardiovascular disease.Lipoprotein-associated phospholipase A2(Lp-PLA2)has attracted much attention as a biomarker of vascular inflammation and vulnerability to atherosclerotic plaque.In the past 20 years,people have conducted a large number of studies on Lp-PLA2 at the gene level,and found that 62％of the genetic factors may affect the variation of Lp-PLA2 activity,and the gene polymorphism may affect the function of Lp-PLA2,thus further affecting the progress of related diseases.This article is to explore the association between Lp-PLA2 gene V279F,A379V,1198T,R92H polymorphism and cardiovascular disease,so as to further understand the effect of gene polymorphism on Lp-PLA2 function.
万方数据
维普
