Type 1 cardiorenal syndrome(CRS-1)is a common complication of acute heart failure(AHF)with a poor prognosis,as AHF causes the worsening of renal function.Current understanding of the pathogenesis and early diagnosis of CRS-1 is inadequate.The pathogenesis of CRS-1 is mainly associated with hemodynamic alterations,neurohormonal activation,inflammatory response and oxidative stress,while biomarkers for early diagnosis of CRS-1 have been expanded to include renal,cardiac,and inflammatory markers in addition to creatinine.This article reviews the research progress of CRS-1 pathogenesis and biomarkers,which can help guide the further research to diagnose CRS-1 early and improve the prognosis of AHF.
关键词
1型心肾综合征/急性心力衰竭/发病机制/生物标志物
Key words
Type 1 cardiorenal syndrome/Acute heart failure/Pathogenesis/Biomarker
维普
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