Hypertension has become one of the most important risk factors,leading to stroke,myocardial infarction,heart failure,kidney failure etc.,and which is also a main cause of death.Therefore,exploring potential therapeutic targets of hypertension and developing new drugs is particularly important to treat hypertension and its comorbidities.This review summarizes recent insights into the potential therapeutic targets,including Elabela/Apelin-APJ axis,family with sequence similarity 3,member D,fibroblast growth factor 21 and the allosteric modulation of angiotensin Ⅱ type 1 receptor,aiming to provide new insights to improve conventional antihypertensive drugs and develop novel targets for the treatment of hypertension.
维普
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