Vascular aging refers to the process of structural remodeling and functional decline of the vasculature due to age,environment and inflammatory stimuli,which is an important factor contributing to the development of cardiovascular disease in the elderly.In this paper,we explore the role of vascular aging in cardiovascular disease in the elderly by providing an overview of the main mechanisms involved in the occurrence of vascular senescence(telomere depletion,mitochondrial dysfunction,oxidative stress,inflammatory response,renin-angiotensin-aldosterone system and epigenetics)and by providing an overview of vascular aging and its mechanisms in terms of their relevance to cardiovascular disease in the elderly.Looking ahead to the future,through more in-depth research on key signaling molecules,conduction pathways,and regulatory modes involved in the mechanism of vascular aging in elderly cardiovascular disease,more possibilities will be provided for delaying vascular aging and preventing and treating elderly cardiovascular disease.
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