Heart failure is one of the most prevalent diseases in the world,and inflammation plays a crucial role in the occurrence and development of heart failure and its comorbidities.A large number of studies have shown that the Toll-like receptor 4 signaling pathway can cause damage to the myocardium by mediating different inflammatory factors.Therefore,it has recently been found that the Toll-like receptor 4 signaling pathway can be used to predict the severity and prognosis of heart failure and its comorbidities,and at the same time,it can also be used as a target for many new anti-heart failure drugs to improve symptoms and benefit patients with heart failure.This article reviews the application value of the Toll-like receptor 4 signaling pathway in the above two aspects in heart failure.
Toll-like receptor 4Heart failureDisease prognosisDrug targetPredicted value
维普
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