Abdominal aortic aneurysm(AAA)is a vascular disease characterized by the continuous dilation of the abdominal aorta wall,and its rupture often leads to severe consequences.Vascular smooth muscle cells(VSMCs)are a crucial component of the vascular wall,responsible for regulating vessel diameter and blood flow to maintain normal blood circulation and pressure.The mitochondria of VSMCs serve as the center of cellular oxidative metabolism,playing a significant role in energy production and cell metabolism.In recent years,an increasing amount of research has shown a close association between mitochondrial dysfunction in VSMCs and the development of AAA.This article explores the research progress on VSMCs'mitochondrial damage in the context of AAA development,focusing on four aspects:mitochondrial involvement in oxidative stress and inflammation,mitochondrial DNA damage,mitochondrial dynamics abnormalities,and cell metabolism.The aim is to provide new strategies for the future treatment and prevention of AAA.
关键词
腹主动脉瘤/血管平滑肌细胞/线粒体/氧化应激/线粒体DNA损伤
Key words
Abdominal aortic aneurysm/Vascular smooth muscle cells/Mitochondria/Oxidative stress/Mitochondrial DNA damage
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