Diagnosis,Genetics and Risk Stratification of Brugada Syndrome
Brugada syndrome(BrS)is a severe hereditary malignant arrhythmia with multiple clinical manifestations of pleomorphic ventricular tachycardia and ventricular fibrillation,causing syncope and even sudden death.As a hereditary heart disease,BrS has extensive genetic heterogeneity and is also affected by age,gender,family history,etc.As a result,there is currently no unified standard to judge the patient's disease status and prognosis.Risk stratification of patients with BrS remains challenging.Numerous studies have shown that risk scores not only play a role in identifying patients with arrhythmia and sudden cardiac death,but also include factors such as clinical symptoms,heredity,comorbidity,age and gender in the comprehensive score,which may help stratify patients'risk and guide patient individualized treatment.Here is a brief review of the current diagnosis,genetics and risk stratification of BrS.
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