Pyroptosis is a novel pro-inflammatory programmed cell death modality,which is initiated by NOD-like receptor thermal protein domain associated protein 3 inflammasome activation,and the active N-terminus of gasdermin D destroys the integrity of the cell membrane,leading to cell death,and then triggering an inflammatory cascade to aggravate tissue damage.Studies have shown that pyroptosis may be involved in the development of myocardial ischemia reperfusion injury(MIRI).MIRI is one of the important reasons limiting the clinical efficacy of acute myocardial infarction.Drug targeting pyroptosis can save myocardial injury caused by pyroptosis in a disease model of MIRI.This article reviews the role of pyroptosis in myocardial ischemia reperfusion injury,and discusses possible therapeutic targets on this basis.
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