巨噬细胞治疗缺血心肌的研究进展
Macrophage Therapy for Ischemic Myocardium
黄爱宝 1张少衡1
作者信息
- 1. 暨南大学附属广州红十字会医院,广东广州 510000
- 折叠
摘要
心血管疾病是全球主要死因,而M2巨噬细胞在心血管疾病中起着主导作用.了解M2巨噬细胞的作用机制有助于制定相应的治疗策略.M2巨噬细胞具有消除炎症和修复心肌的能力,在心肌梗死后,减小梗死灶的大小,减少梗死后的纤维化,改善心肌重构.许多研究发现,通过调节细胞间的通信、巨噬细胞相关基因和蛋白的表达,以及药物靶向作用,M2巨噬细胞在心肌梗死中的炎症调节作用可得到增强,从而进一步改善心肌修复,减少心肌梗死后并发症的发生.现重点综述M2巨噬细胞在缺血心肌治疗中的进展.
Abstract
Cardiovascular disease is the leading cause of death worldwide,and M2 macrophages play a dominant role in cardiovascular diseases.Understanding the mechanisms of M2 macrophages are beneficial for developing corresponding treatment strategies.M2 macrophages have the ability to eliminate inflammation and repair the myocardium after myocardial infarction,reducing infarct size,fibrosis after infarction,and improving myocardial remodeling.Many studies have found that the inflammatory regulation role of M2 macrophages in myocardial infarction can be enhanced by regulating cell communication,the expression of macrophage-related genes and proteins,as well as drug targeting,which could further improve myocardial repair and reduce the occurrence of complications after myocardial infarction.This review focused on the progress of M2 macrophages in the treatment of ischemic myocardium.
关键词
心肌梗死/巨噬细胞/细胞治疗Key words
Myocardial infarction/Macrophage/Cell therapy引用本文复制引用
基金项目
广州市科技计划项目(202002030081)
出版年
2024
NETL
NSTL
万方数据