Cardiovascular disease is the leading cause of death worldwide,and M2 macrophages play a dominant role in cardiovascular diseases.Understanding the mechanisms of M2 macrophages are beneficial for developing corresponding treatment strategies.M2 macrophages have the ability to eliminate inflammation and repair the myocardium after myocardial infarction,reducing infarct size,fibrosis after infarction,and improving myocardial remodeling.Many studies have found that the inflammatory regulation role of M2 macrophages in myocardial infarction can be enhanced by regulating cell communication,the expression of macrophage-related genes and proteins,as well as drug targeting,which could further improve myocardial repair and reduce the occurrence of complications after myocardial infarction.This review focused on the progress of M2 macrophages in the treatment of ischemic myocardium.
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