Diabetic cardiomyopathy(DCM)is a leading cause of death among patients with diabetes,yet the precise regulatory mechanisms remain unclear.Recent studies have discovered that the innate immune response plays a central role in the progression of DCM.Pattern recognition receptors are critical molecules that execute the functions of the innate immune system,including Toll-like receptor,NOD-like receptor,retinoic acid-inducible gene-Ⅰ-like receptor,C-type lectin receptor,absent in melanoma 2-like receptor,scavenger receptor,and cyclic GMP-AMP synthase.This review summarizes the research progress on the role of these pattern recognition receptors in DCM,aiming to provide new insights and targets for the clinical treatment of DCM.
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