Complement C1q/tumor necrosis factor-related protein(CTRP)is a highly conserved lipocalin paralog with similar structure and function as lipocalin.Atherosclerosis is the main pathological manifestation of coronary heart disease.CTRP family plays wide-ranging roles in cardiovascular diseases,such as atherosclerosis,ischemic cardiomyopathy,and hypertension.Numerous studies have shown that among the complement CTRP family,CTRP1 and CTRP5 promote the development of atherosclerosis,and CTRP3,CTRP6,CTRP9,CTRP12,CTRP13,and CTRP15 inhibit atherosclerotic progression.This article reviews recent advances on the role in atherosclerosis.
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