补体C1q/肿瘤坏死因子相关蛋白家族在动脉粥样硬化中的作用
Role of the Complement C1q/Tumour Necrosis Factor-Related Protein Family in Atherosclerosis
桂琳 1董睿 2吴雪莲 1王黔艳 1何艳 1尹虹1
作者信息
- 1. 华中科技大学同济医学院附属梨园医院心血管中心,湖北武汉 430077
- 2. 华中科技大学同济医学院附属梨园医院呼吸内科,湖北武汉 430077
- 折叠
摘要
补体C1q/肿瘤坏死因子相关蛋白(CTRP)是高度保守的脂联素旁系同源物,具有与脂联素相似的结构及功能.动脉粥样硬化是冠心病的主要病理表现,CTRP家族在动脉粥样硬化、缺血性心肌病、高血压等心血管疾病中作用广泛.大量的研究数据表明补体CTRP家族中,CTRP1、CTRP5促进动脉粥样硬化的发展,CTRP3、CTRP6、CTRP9、CTRP12、CTRP13、CTRP15可抑制动脉粥样硬化的进程.现综述CTRP在动脉粥样硬化中作用的最新进展.
Abstract
Complement C1q/tumor necrosis factor-related protein(CTRP)is a highly conserved lipocalin paralog with similar structure and function as lipocalin.Atherosclerosis is the main pathological manifestation of coronary heart disease.CTRP family plays wide-ranging roles in cardiovascular diseases,such as atherosclerosis,ischemic cardiomyopathy,and hypertension.Numerous studies have shown that among the complement CTRP family,CTRP1 and CTRP5 promote the development of atherosclerosis,and CTRP3,CTRP6,CTRP9,CTRP12,CTRP13,and CTRP15 inhibit atherosclerotic progression.This article reviews recent advances on the role in atherosclerosis.
关键词
C1q/肿瘤坏死因子相关蛋白/冠心病/动脉粥样硬化Key words
C1q/tumor necrosis factor-related protein/Coronary heart disease/Atherosclerosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据