Radiation-induced heart disease(RIHD)is a collective term for a range of radiation-induced cardiovascular complications that manifest clinically as coronary artery disease,cardiomyopathy,valvular disease,pericarditis,pericardial effusions and arrhythmias etc.At present,it is accepted that mitochondrial dysfunction is one of the main mechanisms of RIHD.Cardiomyocytes contain a large number of mitochondria,and in response to radiation stimulation,mitochondrial genes,mitochondrial membranes,oxidative respiratory chain,and mitochondrial dynamics all undergo variable degrees of functional changes that can affect cardiomyocyte outcome.In this paper,we review the research on mitochondrial dysfunction mechanisms in RIHD as follows.
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