Heart failure is a global cardiovascular disease characterized by poor clinical prognosis and high mortality.KATP channel play pivotal roles in excitable cells and link cellular metabolism with membrane excitability.The action potential converts electricity into dynamics by ion channels mediated ion-exchange generate the systole,which composes every single heartbeat.Activation of the KATP channel repolarizes the membrane potential and decreases the occurrence of early after-depolarization-mediated arrhythmias.Cardiac KATP channel have less function under physiological conditions and open during severe and prolonged anoxia due to reduced adenosine triphosphate/adenosine diphosphate ratio,lessening cellular excitability,thus preventing action potential generation and cell contraction.Accumulated evidence indicated that ferroptosis may cause damage to the KATP channel.Hence,we describe the potential damage role of ferroptosis in the KATP channel,lucubrating the potential mechanisms and insight into the clinical therapeutic strategy.
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