Objective To analyze the prevalence of various components of metabolic syndrome(MetS)[waist circumference,blood pressure,high-density lipoprotein cholesterol(HDL-C),triglycerides(TG),fasting blood glucose]in patients with juvenile idiopathic arthritis(JIA),and to explore whether JIA is associated with the risk of metabolic abnormality and its related factors.Methods There were 140 patients with JIA in The Affiliated Hospital of Southwest Medical University,The Third People's Hospital of Chengdu,and The Chengdu Women's and Children's Center Hospital from January 2020 to December 2022.140 children who underwent physical examination from the child health clinic were selected as the control group.The prevalence of components of MetS in the study group and control group were compared,and the possible factors of metabolic abnormalities in patients with JIA were explored.Results There were statistical differences in HDL-C and TG between the two groups(P＜0.05),and no statistical differences in body mass index,waist circumference,blood pressure,and fasting blood glucose(P＞0.05).Compared with the control group,the detection rate of two abnormalities of MetS was higher in patients with JIA(P=0.004).There were no statistical differences in the detection rate of three or more abnormalities of MetS between groups(P＞0.05).The patients with JIA had significant reductions in albumin and hemoglobin and significant increases in aspertate transaminase and creatinine(P＜0.05),while there were no statistical differences in alanine transaminase,urea and uric acid between groups(P＞0.05).The level of disease activity(DAS28)was positively correlated with fasting blood glucose(r=0.240,P=0.004),and negatively correlated with HDL-C(r=-0.402,P＜0.001),whereas no relationship with body mass index,waist circumference,blood pressure,and TG(P＞0.05).In multivariate logistic regression analysis,the level of DAS28 and disease duration were found to be independent risk factors for MetS(P＜0.05).Conclusion JIA was not significantly associated with MetS,but the level of DAS28 was associated with an increased risk of MetS,suggesting that inflammatory activity in patients with JIA may play an important role in MetS.
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