In clinical practice,heart failure with preserved ejection fraction(HFpEF)is defined as a type of heart failure with accompanying symptoms and signs of heart failure and left ventricular ejection fraction≥50％.It is characterized by abnormalities in heart structure/function related to HFpEF,such as left ventricular hypertrophy,left atrial enlargement and diastolic dysfunction,often with multiple comorbidities.It is the result of multiple pathogenic factors working together.At present,the understanding of the pathogenesis of HFpEF is still insufficient,but there are still common pathogenic pathways that ultimately lead to the occurrence and development of the disease.This is mainly related to metabolic remodeling.The research progress on the molecular mechanism of metabolic remodeling in HFpEF is summarized as follows.
关键词
射血分数保留的心力衰竭/代谢重塑/代谢性炎症
Key words
Heart failure with preserved ejection fraction/Metabolic remodeling/Metabolic inflammation
维普
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