β-Blocker is the cornerstone of the treatment of various cardiovascular diseases and is widely used in the treatment of heart failure,arrhythmia,hypertension and ischemic heart disease.This paper reviews the evidence for β-blocker-related effects in these disease conditions,as well as the recommendations of clinical practice guidelines for the use of β-blocker,with the hope of facilitating the precise use of β-blocker in these disease conditions.