摘要
主动脉瓣狭窄(AS)合并心脏淀粉样变(CA)在老年群体中并不罕见.由于AS和CA有相似的临床、影像和实验室检查表现使其诊断具有挑战性,而AS-CA患者较单独AS患者预后更差,延迟诊断将增加死亡风险.随着诊断成像技术发展,多模态、多参数综合评估方法和有效药物的研发有助于AS-CA的早期诊断和治疗,从而有效改善患者预后.现总结AS-CA的流行病学、病理生理学、发病机制、诊断和治疗的研究进展.
Abstract
The prevalence of the coexistence of aortic stenosis(AS)and cardiac amyloidosis(CA)is not uncommon in elderly.The diagnosis of AS-CA is challenging due to the similar clinical,imaging,and laboratory features between the two diseases.However,patients with AS-CA have a worse prognosis than patients with AS alone,and delayed diagnosis increases the risk of death.With the development of imaging techniques,The multimodal and multiparameter comprehensive assessment is conducive to a diagnosis of early AS-CA at present,as to formulate personalized treatment and improve patient outcomes.This article reviews the recent progress in the epidemiology,pathophysiology,pathogenesis,diagnosis,and treatment of AS-CA.
基金项目
辽宁省教育厅基本科研项目(LJKMZ20221139)
NETL
NSTL
万方数据