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主动脉瓣狭窄合并心脏淀粉样变的研究进展

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主动脉瓣狭窄(AS)合并心脏淀粉样变(CA)在老年群体中并不罕见。由于AS和CA有相似的临床、影像和实验室检查表现使其诊断具有挑战性,而AS-CA患者较单独AS患者预后更差,延迟诊断将增加死亡风险。随着诊断成像技术发展,多模态、多参数综合评估方法和有效药物的研发有助于AS-CA的早期诊断和治疗,从而有效改善患者预后。现总结AS-CA的流行病学、病理生理学、发病机制、诊断和治疗的研究进展。
Concomitant Aortic Stenosis and Cardiac Amyloidosis
The prevalence of the coexistence of aortic stenosis(AS)and cardiac amyloidosis(CA)is not uncommon in elderly.The diagnosis of AS-CA is challenging due to the similar clinical,imaging,and laboratory features between the two diseases.However,patients with AS-CA have a worse prognosis than patients with AS alone,and delayed diagnosis increases the risk of death.With the development of imaging techniques,The multimodal and multiparameter comprehensive assessment is conducive to a diagnosis of early AS-CA at present,as to formulate personalized treatment and improve patient outcomes.This article reviews the recent progress in the epidemiology,pathophysiology,pathogenesis,diagnosis,and treatment of AS-CA.

Aortic stenosisCardiac amyloidosisMultimodal imaging

龙颉婧、邱悦、马春燕、陈昕

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中国医科大学附属第一医院心血管超声科辽宁省影像医学临床医学研究中心,辽宁沈阳 110001

主动脉瓣狭窄 心脏淀粉样变 多模态影像

辽宁省教育厅基本科研项目

LJKMZ20221139

2024

心血管病学进展
成都市心血管病研究所,成都市第三人民医院

心血管病学进展

CSTPCD
影响因子:0.932
ISSN:1004-3934
年,卷(期):2024.45(8)