摘要
主动脉夹层(AD)以胸背部剧烈疼痛为主要临床表现,是一种病情危急、发展迅速、病死率极高的心血管疾病,严重影响患者的生命安全.目前对于AD的发病机制研究主要集中在炎症反应、氧化应激、遗传因素等.近年来,研究发现血管平滑肌细胞(VSMC)死亡与AD的发生密切相关.因此,现以VSMC细胞程序性死亡为出发点,归纳目前已知的VSMC细胞程序性死亡类型、诱导因素及其在AD中的作用与发生机制,旨在探讨未来通过抑制VSMC细胞程序性死亡防治AD的潜在价值.
Abstract
Aortic dissection(AD),with severe pain in the chest and back as its main clinical manifestation,is a cardiovascular disease characterized by critical condition,rapid development,and high mortality,seriously affecting patients'life safety.Currently,research on the pathogenesis of AD focuses on inflammatory response,oxidative stress,genetic factors,and so on.In recent years,it has been found that vascular smooth muscle cell death is closely related to the occurrence of AD.Therefore,this study will take vascular smooth muscle cell programmed cell death as the starting point,summarize the currently known types of vascular smooth muscle cell programmed cell death,inducing factors,and their roles and mechanisms of occurrence in AD,with the aim of exploring the potential value of preventing and treating AD by inhibiting vascular smooth muscle cell programmed death in the future.
基金项目
国家自然科学基金面上项目(82370414)
湖北省自然科学基金面上项目(2021CFB421)
湖北省自然科学基金面上项目(2022CFB250)
NETL
NSTL
万方数据