Adult mammalian cardiomyocytes rapidly withdraw from the cell cycle after birth,When cardiomyocytes are injured by ischemia or other factors,the proliferation ability of surviving cardiomyocytes is very limited,and they are replaced by fibrous tissue without contractile ability,which causes adverse cardiac remodeling and ultimately leads to heart failure.In order to improve the prognosis of heart failure patients,it is crucial to develop fundamentally effective treatment strategies.At present,many methods and models have been used to realize the regeneration of cardiomyocytes.This review summarizes the research status of the methods of heart regeneration,aims to clarify various strategies for manipulating heart regeneration and promoting repair after heart injury,and discusses the prospects and challenges of clinical application in the future.
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