Action Mechanism of Remnant Cholesterol and Atherosclerotic Cardiovascular Disease
Atherosclerotic cardiovascular disease(ASCVD)has become one of the greatest threats to global public health and the leading cause of death.Low-density lipoprotein cholesterol(LDL-C)is the vital target for primary and secondary prevention of atherosclerotic diseases.Nevertheless,patients with recommended concentrations in LDL-C still have a considerable residual risk of cardiovascular adverse events.Accumulating studies suggest that levels of remnant cholesterol(RC)were associated with residual risk of cardiovascular adverse events.The mechanisms underlying the effects of RC on ASCVD remain unclear.This article highlights the action mechanisms of RC that have been identified in current studies,which include activation of inflammation,involvement in oxidative stress,promotion of vulnerable plaque formation,acceleration of thrombosis,and insulin resistance.In addition,potential future drugs for RC control are discussed.
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