Soluble Renin/Prorenin Receptor in Cardiovascular Disease and Kidney Disease
Renin/prorenin receptor(PRR)is an important part of renin-angiotensin system,involved in a variety of human pathophysiological processes,and its soluble form is a protein with a relative molecular weight of 28 000 cleaved by site-1 protease,namely sPRR.In recent years,more and more studies have proved that sPRR is closely related to the occurrence and progression of cardiovascular disease and kidney disease,which provides the possibility for it to become a novel biomarker or therapeutic target for these diseases.Due to the lack of specific drugs for diabetes insipidus,heart failure and other diseases,and the poor effect of existing treatments,further understanding of the specific mechanism of sPRR involvement in these diseases is conducive to providing a new direction for diagnosis and treatment.This article aims to review the structure,function and research progress of sPRR in cardiovascular disease and kidney disease.
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