MicroRNA-Mediated Regulation of Cardiomyocyte Injury Following Coronary Microembolisation
Coronary microembolization(CME)occurs in patients with acute coronary syndrome and is primarily caused by atherosclerotic plaque rupture associated with surgery.CME can lead to arrhythmias,reduced coronary blood flow reserve,and cardiac systolic dysfunction.The clinical efficacies of conventional coronary artery dilation,antiplatelet agents,and direct thrombus aspiration after CME are not satisfactory.Studies have found that microRNA(miRNA)specifically binds to the 3'-UTR of inflammatory response,apoptosis,and autophagy-related messenger RNA,and ultimately affect the prognosis of CME.In-depth studies of the role of miRNA in the occurrence and development of CME can not only further understand the mechanism of poor prognosis after CME,but also help to find new targets for its drug treatment.
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