微RNA在冠状动脉微栓塞后心肌损伤的研究进展
MicroRNA-Mediated Regulation of Cardiomyocyte Injury Following Coronary Microembolisation
李蓝鸽 1郑雅璇 1吕婷婷 2李锟 2孔令云 2周博达 2刘芳 2张萍 2薛亚军2
作者信息
- 1. 清华大学附属北京清华长庚医院心血管中心,北京 102218;清华大学医学院 北京 100083
- 2. 清华大学附属北京清华长庚医院心血管中心,北京 102218
- 折叠
摘要
冠状动脉微栓塞(CME)多发生于急性冠脉综合征患者,因手术相关的动脉粥样硬化斑块破裂引发,可导致心律失常、冠状动脉血流储备减少以及心脏收缩功能障碍.CME后常规扩张冠状动脉、抗血小板和直接抽吸血栓的临床疗效不理想.研究发现,微RNA(miRNA)特异结合炎症反应、凋亡、自噬相关信使RNA的3'-UTR,最终影响CME预后.深入研究miRNA在CME发生和发展中的作用,不仅可以进一步了解CME后不良预后机制,还有助于为其药物治疗寻找新的靶点.
Abstract
Coronary microembolization(CME)occurs in patients with acute coronary syndrome and is primarily caused by atherosclerotic plaque rupture associated with surgery.CME can lead to arrhythmias,reduced coronary blood flow reserve,and cardiac systolic dysfunction.The clinical efficacies of conventional coronary artery dilation,antiplatelet agents,and direct thrombus aspiration after CME are not satisfactory.Studies have found that microRNA(miRNA)specifically binds to the 3'-UTR of inflammatory response,apoptosis,and autophagy-related messenger RNA,and ultimately affect the prognosis of CME.In-depth studies of the role of miRNA in the occurrence and development of CME can not only further understand the mechanism of poor prognosis after CME,but also help to find new targets for its drug treatment.
关键词
冠状动脉微栓塞/微RNA/炎症反应/凋亡/自噬Key words
Coronary microembolization/MicroRNA/Inflammatory reaction/Apoptosis/Autophagy引用本文复制引用
基金项目
北京市属医院科研培育计划(PX20210902)
出版年
2024
NETL
NSTL
万方数据