Exercise Modulates Inflammation to Improve Ventricular Remodeling After Myocardial Infarction
Objective To explore effects of exercise on myocardial infarction(MI)-induced ventricular remodeling and the related mechanisms in rats.Methods Adult male Sprague-Dawley rats underwent the left anterior descending coronary artery ligation to generate MI model.The rats were divided into three groups:sham group,MI-sedentariness(MI-Sed)group,MI-exercise(MI-Ex)group.Rats in the MI-Ex group started exercise training 1 week after the MI surgery and lasted for a period of 4 weeks,with 6 days of exercise per week.Rats in all groups were studied at the end of the exercise intervention.Echocardiography was used to evaluate cardiac structure and function.Histological analysis was used to assess pathological changes such as myocardial fibrosis and hypertrophy.Western blotting was used to evaluate nucleotide-binding domain leucine-rich repeat and pyrin domain-containing receptor 3(NLRP3)inflammasome.Results MI rats exhibited abnormal cardiac structure and function,cardiac hypertrophy,and myocardial interstitial fibrosis,accompanied by higher NLRP3 inflammasome expression.4 weeks after exercise,cardiac function was improved in MI rats,cardiac hypertrophy and myocardial interstitial fibrosis was attenuated,with NLRP3 inflammasome inhibition.Conclusion NLRP3 inflammasome was activated in MI-induced ventricular remodeling model.Exercise improved cardiac function,the mechanisms accompanied by attenuation NLRP3 inflammasome activation.
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