Role and Mechanism of T Cell Metabolic Reprogramming in Regulation of Atherosclerosis Progression
Atherosclerosis is the pathological basis of a variety of cardiovascular diseases,and T cells are important immune cells in the process of its development.T cells can be polarized into different phenotypes and play corresponding roles in the development of atherosclerosis.For example,Th1 and Th17 cells have pro-inflammatory effects,while Th2 and Treg cells have anti-inflammatory effects.The proportion and functional imbalance of different T cell subsets are also important reasons for the formation and development of atherosclerotic plaques.Metabolic reprogramming changes the differentiation direction of T cells by regulating metabolic pathways in different microenvironments,thereby changing the development direction of atherosclerosis.This article reviews the proinflammatory and anti-inflammatory roles of T cells in atherosclerosis,focusing on the regulation of atherosclerosis by metabolic reprogramming of proinflammatory/anti-inflammatory T cells and the molecular mechanisms underlying mTOR and AMPK signaling.
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