Ferroptosis is a new cell death method proposed in recent years.It is an iron-dependent cell death process characterized by lipid peroxide accumulation,involving iron metabolism,lipid metabolism and amino acid metabolism.Intracellular iron overload can cause damage to endothelial cells and cardiomyocytes through lipid peroxidation,oxidative stress,inflammation and other pathways,and play an important role in the pathological process of heart failure with preserved ejection fraction(HFpEF).In this paper,the possible correlation between HFpEF and ferroptosis was summarized,so as to provide a reliable theoretical basis for further research on the pathogenesis of HFpEF and provide new ideas for its treatment.
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