Roles of Vascular Smooth Muscle Cell Plasticity in Development of Atherosclerosis as Revealed by Single-Cell Sequencing
Atherosclerosis(AS)is a chronic inflammatory disorder involving multiple immune cells,with vascular smooth muscle cell(VSMC)being crucial at each phase.Prior research has demonstrated that VSMC has notable phenotypic plasticity and can switch between contractile and synthetic phenotypes.In recent years,with the optimization and development of single-cell sequencing technology,several new studies have uncovered that VSMC possesses the capability to transform into other cell types and perform specific functions.This review focuses on the plasticity,regulatory factors,and intricate functions of VSMC in AS process under single-cell sequencing technology,in order to offer a thorough insight into the roles of VSMC and identify new targets and pathways for treating AS clinically.
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