Copper(Cu)is an important cofactor in many physiological functions such as energy metabolism,mitochondrial respiration and antioxidant.Copper ion homeostasis is essential for cell physiological activities.The excess of copper ions in the cell leads to the toxic death of cell proteins.In addition,copper comes in two forms,Cu+and Cu2+.The redox reaction of copper is a double-edged sword for cells.Cardiovascular disease is the leading cause of death worldwide.The cellular mechanism of iron death has been clarified,but the cytotoxic mechanism of copper death induced cardiovascular disease has not been elucidated.This paper reviews the research progress on copper death and cardiovascular disease.
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维普
