首页|替奈普酶在急性ST段抬高型心肌梗死患者中的研究现状与进展

替奈普酶在急性ST段抬高型心肌梗死患者中的研究现状与进展

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急性心肌梗死是一种常见且高发的心血管疾病,是造成死亡、残疾以及严重危害国民健康的重要疾病之一。急性ST段抬高型心肌梗死(STEMI)是急性冠脉综合征里最严重的一种类型,为致残致死的主要原因。急诊经皮冠状动脉介入治疗是急性心肌梗死最高效的再灌注方式,但很难完全恢复冠状动脉血流,微循环灌注仍不理想。替奈普酶是特异性极高的溶栓药物,具有溶栓高效、血管再通率高和出血风险小的特点。近年,关于冠状动脉内注射替奈普酶治疗STEMI的研究日益增多。现就替奈普酶在STEMI的研究现状和进展做一综述。
Current Research Status and Progress of Tenecteplase in Patients with Acute ST Segment Elevation Myocardial Infarction
Acute myocardial infarction(AMI)is a common and highly prevalent cardiovascular disease,which is one of the important diseases causing death,disability and serious harm to national health.Acute ST segment elevation myocardial infarction(STEMI)is the most severe type of acute coronary syndrome and is the leading cause of death and disability.Emergency percutaneous coronary intervention is the most efficient reperfusion modality for patients with AMI,but it is difficult to completely restore coronary blood flow and microcirculatory perfusion remains suboptimal.Tenecteplase is an extremely high specificity thrombolytic drug characterised by high thrombolytic efficiency,high rate of revascularisation and low risk of bleeding.In recent years,there is an increasing amount of research on intracoronary injection of tenecteplase for STEMI.This article reviews the current research status and progress on tenecteplase in STEMI.

TenecteplaseAcute ST segment elevation myocardial infarctionPercutaneous coronary interventionThrombolytic therapy

谭晓丽、范子胤、谢根源、刘向阳、欧阳繁

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吉首大学株洲临床学院,湖南吉首 416000

中南大学湘雅医学院附属株洲医院株洲市中心医院心血管内科,湖南株洲 412000

替奈普酶 急性ST段抬高型心肌梗死 经皮冠状动脉介入治疗 溶栓治疗

国家自然科学基金湖南省自然科学基金

820704262022JJ50106

2024

心血管病学进展
成都市心血管病研究所,成都市第三人民医院

心血管病学进展

CSTPCD
影响因子:0.932
ISSN:1004-3934
年,卷(期):2024.45(9)