Hypertension is a cardiovascular syndrome characterized by elevated systemic arterial blood pressure,which is the most important risk factor for cardiovascular and cerebrovascular diseases,and also the disease with the heaviest global burden.Although the clinical treatment of hypertension has achieved good results,there are still different types of refractory hypertension,and blood pressure cannot meet the standard after active drug treatment.Therefore,in-depth research and application of non-drug treatment have become an important strategy for the treatment of hypertension.This review discusses the progress of neuroregulation in the treatment of hypertension in recent years,mainly including renal denervation,carotid sinus baroreceptor stimulation,vagus nerve stimulation,deep brain stimulation,etc.,and may provide new solutions for the treatment of hypertension in the future.