Leptin as A Potential Mediator of Genetically Predicted Psoriasis with Myocardial Infarction:A Network Mendelian Randomization Study
Objective The network Mendelian randomization(MR)study aimed to assess the causal relationship of genetically predicted psoriasis with myocardial infarction(MI),as well as the role of leptin as a potential mediator.Methods This was a network MR study that utilized genome-wide association study.Network MR was used to evaluate the association between psoriasis and MI,and mediation analysis was used to estimate leptin as a potential mediator for genetically predicted psoriasis with MI.Results This findings indicated that genetically predicted psoriasis was associated with MI(OR=1.004,95％CI 1.001～1.008,P=0.044),which was confirmed in the FinnGen validation dataset(OR=1.006,95％CI1.001～1.012,P=0.025),as well as in the pooled meta-analysis(OR=1.005,95％CI 1.002～1.008,P＜0.001).Further mediation analysis suggested that genetically predicted psoriasis was also associated with leptin(β=0.003,SE=0.001,P=0.047).Moreover,for every unit increased in leptin levels,the risk of MI increased by 13.1％(OR=1.131,95％CI 1.007～1.269,P=0.037).Conclusion This study provided evidence that psoriasis was closely associated with MI,which may be mediated by leptin.Intervention with leptin may help to reduce the incidence of MI in patients with psoriasis.
万方数据
维普
