Ivabradine for Heart Rate Control in Atrial Fibrillation
Control of ventricular rate is recommended for patients with atrial fibrillation(AF).Currently available agents for rate control in AF are limited by adverse effects and their ability to attain target heart rate.By inhibiting funny current(If)of the sinoatrial node,ivabradine reduces sinus heart rate.However,it has been shown that If channels can also be found in atrioventricular node and blocking atrioventricular nodal If slows atrioventricular conduction,resulting in lower ventricular rates during AF.Ivabradine has drawn recent interest as a rate control agent for AF.In this review,we focus on the basic and clinical evidence for ventricular rate control of ivabradine in AF.
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