伊伐布雷定用于心房颤动心室率控制的研究进展
Ivabradine for Heart Rate Control in Atrial Fibrillation
王競婧 1姚建晗 1黄新苗 1郭志福 1曹江1
作者信息
- 1. 海军军医大学第一附属医院心血管内科,上海 200433
- 折叠
摘要
控制心室率是心房颤动(AF)治疗的重要方面.目前可用于AF心室率控制的药物受到副作用和疗效的限制.伊伐布雷定通过抑制窦房结funny电流(If),降低窦性心室率.有研究表明,房室结中也存在If通道,阻断房室结If会减慢房室传导,可降低AF的心室率.近期伊伐布雷定用于控制AF心室率治疗引起较多关注.现就伊伐布雷定在AF心室率控制方面的基础和临床研究做一综述.
Abstract
Control of ventricular rate is recommended for patients with atrial fibrillation(AF).Currently available agents for rate control in AF are limited by adverse effects and their ability to attain target heart rate.By inhibiting funny current(If)of the sinoatrial node,ivabradine reduces sinus heart rate.However,it has been shown that If channels can also be found in atrioventricular node and blocking atrioventricular nodal If slows atrioventricular conduction,resulting in lower ventricular rates during AF.Ivabradine has drawn recent interest as a rate control agent for AF.In this review,we focus on the basic and clinical evidence for ventricular rate control of ivabradine in AF.
关键词
心房颤动/funny电流/伊伐布雷定/心室率控制/房室结Key words
Atrial fibrillation/Funny current/Ivabradine/Heart rate control/Atrioventricular node引用本文复制引用
出版年
2024
NETL
NSTL
万方数据