人附睾蛋白4在心肾疾病中的研究进展
Human Epididymis Protein 4 in Cardiovascular and Renal Diseases
刘志斌 1唐毅 2胡政琪 1刘天承 1彭建强 2何晋2
作者信息
- 1. 湖南师范大学附属第一医院湖南省人民医院心血管内科,湖南长沙 410005
- 2. 湖南师范大学附属第一医院湖南省人民医院心血管内科,湖南长沙 410005;湖南省心力衰竭临床医学研究中心,湖南长沙 410005
- 折叠
摘要
人附睾蛋白4(HE4)为具有2个乳清酸性蛋白四二硫化物核心结构域、124个氨基酸的多肽,是一种乳清酸性蛋白,属于蛋白酶抑制剂家族中的一种.HE4目前广泛应用于妇科相关疾病的诊断及预后评估,近年来研究显示HE4在心血管及肾脏疾病患者中呈现较高水平表达,尤其是在心力衰竭、急性冠脉综合征和心肌病等心血管疾病及慢性肾脏病等肾脏疾病中扮演着重要角色.现对HE4在心血管及肾脏疾病中的研究现状做一综述.
Abstract
Human epididymis protein 4(HE4)is a peptide with 2 whey acidic protein four-disculfidecore domains,consisting of 124 amino acids.It is a whey acidic protein and belongs to the family of protease inhibitors.HE4 is currently widely used in the diagnosis and prognosis assessment of gynecological diseases.In recent years,studies have shown that HE4 exhibits high levels of expression in patients with cardiovascular and renal diseases,especially playing an important role in cardiovascular diseases such as heart failure,acute coronary syndrome,cardiomyopathy,as well as chronic kidney disease.This article provides an overview of the current research status of HE4 in cardiovascular and renal diseases.
关键词
人附睾蛋白4/心力衰竭/急性冠脉综合征/心肌病/慢性肾脏病Key words
Human epididymis protein 4/Heart failure/Acute coronary syndrome/Cardiomyopathy/Chronic kidney disease引用本文复制引用
出版年
2024
NETL
NSTL
万方数据